neural progenitor cell을 이용하게 되었다. 또한 신경 줄기세포의 분화 범위는 혈관 세포를 비롯하여 매우 다양하다는 특징과 Type I 당뇨의 근본적인 치료방법을 위한 시도가 증가하고 있는 사회적인 배경 또한 연구의 동기가 되었다.
실험의 과정은 다음과 같았다. 우선 사람의 뇌로부터 얻은 humanneural progen
Mid-1800s - Beginning research of Embryo
1908 – ‘StemCell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stemcell
1981 - Embryonic stemcell
1998 - Human's embryonic stemcell
2001 – First human embryo cloning
(중략)
2.1 Adult StemCell - How?From Bone Marrow
HSCs and MSCs are rich in b
1908 - The term "stemcell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stemcells.
1998 - James Thomson and coworkers derive the first human embryonic stemcell line at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
A. Limitations
So far we have seen a new approach of using stemcells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neuralstemcells esp
Stemcell calssification
1. Based upon location
Embryonic stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
3. 암화에 의한 세포주 확립
동물세포를 이용한 연구 발전에 기여
4. Sato등에 의해 무혈청 배양법 확립
1960. 무혈청 배양 시도
1963-5(Ham) 혈청 공급 없이
CHO cell cloning
1970(Sato) 혈청 대신 호르몬
첨가 cell line 무혈청 배양
성공
Human embryonal kidney, SV40 and large T antigen transformed
remove the nucleus from the egg
cell fusion
cultivate fertilized egg in the lab for a week.
extract stemcells from the embryo
develop them into specialized body cells
- blood, nerve, spinal cords
Potential for discovering treatments and cures.
Improving the quality and lengthen human lives.
- Cornerstone of medical technology development.
Stemcell research allowed only
of the body.
* Parkinson’s , Alzheimer’s Disease
* Heart Diseases, Stroke and Diabetes
* Birth Defects
* Spinal Cord Injuries
* Replace Damaged Organs,
Play a major role in cancer
potential for finding treatments and cures
be used to test new drugs
cannot be defined to living things
embryonic stemcells ≠human cloning
question of values
Discovery of the iPS cell
Expect to solve the problems of ES cells
How to think?
Active factor(protein) in ES cells skin cells
Aug, 2006, Pro. Yamanaka ’s laboratory in Kyoto produced ‘pluripotent cells’
Nov, 2007, the first Human iPS cells
iPS cells are a type of pluripotent stemcell
artificially derived from a differentiated cell,
by inducing a “forced”